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Tumour–node–metastasis staging of human papillomavirus negative upper aerodigestive tract cancers: a critical appraisal

Published online by Cambridge University Press:  08 October 2015

U Aydil ,
U Duvvuri ,
Y Kizil  and
A Köybaşioğlu
U Aydil*
Affiliation:
Department of Otorhinolaryngology, Head & Neck Surgery, Gazi University School of Medicine, Ankara, Turkey
U Duvvuri
Affiliation:
Department of Otorhinolaryngology, Head & Neck Surgery, University of Pittsburgh Medical Center, Pennsylvania, USA Section of Otolaryngology, Veterans Affairs Pittsburgh Health System, Pennsylvania, USA
Y Kizil
Affiliation:
Department of Otorhinolaryngology, Head & Neck Surgery, Gazi University School of Medicine, Ankara, Turkey
A Köybaşioğlu
Affiliation:
Department of Otorhinolaryngology, Head & Neck Surgery, Memorial Ankara Hospital, Turkey
*
Address for correspondence: Dr U Aydil, Gazi Üniversitesi Tıp Fakültesi KBB AD, 06500 Beşevler, Ankara, Turkey Fax: +90 312 202 4357 E-mail: utkuaydil@yahoo.com
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Abstract

Objective:

The tumour–node–metastasis staging system has a dynamic structure that is continuously being updated as scientific data develops. This review discusses some suggested revisions on tumour–node–metastasis staging of human papillomavirus negative upper aerodigestive tract cancers.

Methods:

The seventh edition of The American Joint Committee on Cancer Staging Manual was reviewed and important issues that could be considered for revision were identified and discussed.

Results:

According to our assessment of the oncological outcomes of previous studies, the following factors should be considered for revision: anterior commissure involvement and subglottic extension in laryngeal cancers; underlying bone involvement in hard palate and upper alveolar ridge cancers; tumour thickness in oral cancers; and extracapsular spread and carotid artery involvement in neck metastases.

Conclusion:

Sufficient data on the prognostic importance of these issues have been reported. Suggested revisions in line with current knowledge on the clinical behaviour of upper aerodigestive tract cancers would improve the relevancy of staging.

Keywords

Neoplasm StagingHead and Neck NeoplasmsLarynxMouthLymphatic Metastasis
Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 12 , December 2015 , pp. 1148 - 1155
Copyright
Copyright © JLO (1984) Limited 2015 

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