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Geographical distribution and epidemiological features of Old World Leishmania infantum and Leishmania donovani foci, based on the isoenzyme analysis of 2277 strains

Published online by Cambridge University Press:  12 November 2012

FRANCINE PRATLONG ,
PATRICK LAMI ,
CHRISTOPHE RAVEL ,
YVES BALARD ,
JACQUES DEREURE ,
GHISLAINE SERRES ,
FOUAD EL BAIDOURI  and
JEAN-PIERRE DEDET
FRANCINE PRATLONG
Affiliation:
Université Montpellier 1 (UFR Médecine), Centre National de référence des leishmanioses, UMR «MIVEGEC» (CNRS 5290, IRD 224, UM1, UM2), Département de Parasitologie-Mycologie (Professeur Patrick Bastien), CHRU de Montpellier, 39, Avenue Charles Flahault, 34295 Montpellier Cedex 5, France
PATRICK LAMI
Affiliation:
Université Montpellier 1 (UFR Médecine), Centre National de référence des leishmanioses, UMR «MIVEGEC» (CNRS 5290, IRD 224, UM1, UM2), Département de Parasitologie-Mycologie (Professeur Patrick Bastien), CHRU de Montpellier, 39, Avenue Charles Flahault, 34295 Montpellier Cedex 5, France
CHRISTOPHE RAVEL
Affiliation:
Université Montpellier 1 (UFR Médecine), Centre National de référence des leishmanioses, UMR «MIVEGEC» (CNRS 5290, IRD 224, UM1, UM2), Département de Parasitologie-Mycologie (Professeur Patrick Bastien), CHRU de Montpellier, 39, Avenue Charles Flahault, 34295 Montpellier Cedex 5, France
YVES BALARD
Affiliation:
Université Montpellier 1 (UFR Médecine), Centre National de référence des leishmanioses, UMR «MIVEGEC» (CNRS 5290, IRD 224, UM1, UM2), Département de Parasitologie-Mycologie (Professeur Patrick Bastien), CHRU de Montpellier, 39, Avenue Charles Flahault, 34295 Montpellier Cedex 5, France
JACQUES DEREURE
Affiliation:
Université Montpellier 1 (UFR Médecine), Centre National de référence des leishmanioses, UMR «MIVEGEC» (CNRS 5290, IRD 224, UM1, UM2), Département de Parasitologie-Mycologie (Professeur Patrick Bastien), CHRU de Montpellier, 39, Avenue Charles Flahault, 34295 Montpellier Cedex 5, France
GHISLAINE SERRES
Affiliation:
Université Montpellier 1 (UFR Médecine), Centre National de référence des leishmanioses, UMR «MIVEGEC» (CNRS 5290, IRD 224, UM1, UM2), Département de Parasitologie-Mycologie (Professeur Patrick Bastien), CHRU de Montpellier, 39, Avenue Charles Flahault, 34295 Montpellier Cedex 5, France
FOUAD EL BAIDOURI
Affiliation:
Université Montpellier 1 (UFR Médecine), Centre National de référence des leishmanioses, UMR «MIVEGEC» (CNRS 5290, IRD 224, UM1, UM2), Département de Parasitologie-Mycologie (Professeur Patrick Bastien), CHRU de Montpellier, 39, Avenue Charles Flahault, 34295 Montpellier Cedex 5, France
JEAN-PIERRE DEDET*
Affiliation:
Université Montpellier 1 (UFR Médecine), Centre National de référence des leishmanioses, UMR «MIVEGEC» (CNRS 5290, IRD 224, UM1, UM2), Département de Parasitologie-Mycologie (Professeur Patrick Bastien), CHRU de Montpellier, 39, Avenue Charles Flahault, 34295 Montpellier Cedex 5, France
*
*Corresponding author: Département de Parasitologie-Mycologie, 39 avenue Charles Flahault, 34295 Montpellier Cedex 5, France. Tel: 334 67 33 23 50. Fax: 334 67 33 23 58. E-mail: parasito@univ-montp1.fr
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Summary

A series of 2277 Leishmania strains from Old World visceral leishmaniasis foci, isolated between 1973 and 2008, were studied by isoenzyme analysis. The strains were obtained from humans, domestic and wild carnivores, rodents and phlebotomine sandflies, and came from 36 countries. In all, 60 different zymodemes were identified and clustered by a phenetic analysis into 3 different groups corresponding to the typically visceralizing species L. donovani (20 zymodemes, 169 strains), L. archibaldi (3 zymodemes, 46 strains) and L. infantum (37 zymodemes, 2,062 strains). The taxonomic position of these isoenzymatic groups is discussed in view of contradictory results obtained from recent molecular studies.

Keywords

visceral leishmaniasisLeishmania infantumLeishmania donovaniLeishmania archibaldiisoenzymatic identificationOld World
Type
Research Article
Information
Parasitology , Volume 140 , Issue 4 , April 2013 , pp. 423 - 434
Copyright
Copyright © Cambridge University Press 2012

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