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Topography of the long- to middle-wavelength sensitive cone ratio in the human retina assessed with a wide-field color multifocal electroretinogram

Published online by Cambridge University Press:  03 July 2008

JAMES A. KUCHENBECKER ,
MANISHA SAHAY ,
DIANE M. TAIT ,
MAUREEN NEITZ  and
JAY NEITZ
JAMES A. KUCHENBECKER
Affiliation:
Department of Ophthalmology, and Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin
MANISHA SAHAY
Affiliation:
Department of Ophthalmology, and Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin
DIANE M. TAIT
Affiliation:
Department of Ophthalmology, and Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin
MAUREEN NEITZ
Affiliation:
Department of Ophthalmology, and Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin
JAY NEITZ*
Affiliation:
Department of Ophthalmology, and Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin
*
Address correspondence and reprint requests to: Jay Neitz, Department of Ophthalmology, The Eye Institute, 925 North 87thStreet, Milwaukee, WI 53226-4812. E-mail: jneitz@mcw.edu
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Abstract

The topographical distribution of relative sensitivity to red and green lights across the retina was assayed using a custom-made wide-field color multifocal electroretinogram apparatus. There were increases in the relative sensitivity to red compared to green light in the periphery that correlate with observed increases in the relative amount of long (L) compared to middle (M) wavelength sensitive opsin mRNA. These results provide electrophysiological evidence that there is a dramatic increase in the ratio of L to M cones in the far periphery of the human retina. The central to far peripheral homogeneity in cone proportions has implications for understanding the developmental mechanisms that determine the identity of a cone as L or M and for understanding the circuitry for color vision in the peripheral retina.

Keywords

Cone photopigmentsCone topographyCone photo pigment gene expressionMultifocal electroretinogram
Type
Research Article
Information
Visual Neuroscience , Volume 25 , Issue 3 , May 2008 , pp. 301 - 306
Copyright
Copyright © Cambridge University Press 2008

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