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Myocardial infarction in a 17-year-old patient due to neurofibromatosis-associated coronary aneurysm

Published online by Cambridge University Press:  20 July 2012

Harun Evrengul ,
Dogu I. Kilic ,
Mustafa Zungur ,
Yusuf I. Alihanoglu  and
Halil Tanriverdi
Harun Evrengul
Affiliation:
Department of Cardiology, Sifa University, Izmir, Turkey
Dogu I. Kilic*
Affiliation:
Department of Cardiology, Pamukkale University, Denizli, Turkey
Mustafa Zungur
Affiliation:
Department of Cardiology, Sifa University, Izmir, Turkey
Yusuf I. Alihanoglu
Affiliation:
Department of Cardiology, Pamukkale University, Denizli, Turkey
Halil Tanriverdi
Affiliation:
Department of Cardiology, Pamukkale University, Denizli, Turkey
*
Correspondence to: Dr I. D. Kilic, MD, Department of Cardiology, Pamukkale University, Pamukkale University Hospital, Denizli 20070, Turkey. Tel: +90 5326434948; Fax: + 90 2134922; E-mail: idogukilic@gmail.com
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Abstract

Neurofibromatosis is an autosomal dominant multi-system genetic disorder. Extra-cardiac vascular manifestations of neurofibromatosis have been previously described in many reports. However, coronary arterial involvements have been rarely described. A 17-year-old girl with neurofibromatosis presented to our institute with subacute myocardial infarction. Coronary angiogram revealed an aneurysm with thrombus in the left anterior descending artery.

Keywords

Youngcoronary thrombus
Type
Brief Reports
Information
Cardiology in the Young , Volume 23 , Issue 3 , June 2013 , pp. 454 - 456
Copyright
Copyright © Cambridge University Press 2012 

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References

1. Hamilton, SJ, Friedman, JM. Insights into the pathogenesis of neurofibromatosis vasculopathy. Clin Genet 2000; 58: 341–344.Google Scholar
2. Kossler, N, Stricker, S, Rödelsperger, C, et al. Neurofibromin (Nf1) is requiered for skeletal muscle development. Hum Mol Genet 2011; 20: 2697–2709.CrossRefGoogle Scholar
3. Friedman, JM, Arbiser, J, Epstein, JA, et al. Cardiovascular disease in neurofibromatosis 1: report of the NF1 Cardiovascular Task Force. Genet Med 2002; 4: 105–111.CrossRefGoogle ScholarPubMed
4. Bilsel, T, Akbulut, T, Terzi, S, Sayar, N, Yesilcimen, K. Neurofibromatosis as a cause of multiple coronary aneurysms. Heart Vessels 2005; 20: 128–130.CrossRefGoogle ScholarPubMed
5. Kandarpa, K, Stoll, JF, Reiss, C, Rutherford, JD, Cohn, LM. A case of neurofibromatosis associated with a coronary artery aneurysm and myocardial infarction. Cardiovasc Intervent Radiol 1988; 11: 143–145.Google Scholar
6. Ruggieri, M, D'Arrigo, G, Abbate, M, Distefano, A, Upadhyaya, M. Multiple coronary artery aneurysms in a child with neurofibromatosis type 1. Eur J Pediatr 2000; 159: 477–480.CrossRefGoogle Scholar
7. Trevelyan, J, Been, M, Patel, R. Multiple coronary aneurysms in a patient with neurofibromatosis type 1: case report and intravascular ultrasound of aneurysm. Postgrad Med J 2001; 77: 45–47.CrossRefGoogle Scholar
8. Fuchi, T, Ishimoto, N, Kajinami, T, Kajinami, M, Ohmichi, N, Kinoshita, M. A 23-year-old patient with neurofibromatosis associated with acute myocardial infarction, vasospasm and a coronary artery ectasis. Intern Med 1997; 36: 618–623.Google Scholar
9. Talay, S, Dag, O, Ozmen, S, Erkut, B. Surgical management of coronary artery stenosis and peripheral artery occlusive disease of the lower extremity in a patient with neurofibromatosis: report of a case. Surg Today 2011; 41: 713–716.CrossRefGoogle Scholar
10. Norton, KK, Xu, J, Gutmann, DH. Expression of the neurofibromatosis 1 gene product, neurofibromin, in blood vessel endothelial cells and smooth muscle. Neurobiol Dis 1995; 2: 13–21.CrossRefGoogle ScholarPubMed