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Several recent surveys (HERACLES, NGLS, KINGFISH, VNGS) have provided us with sensitive high-resolution observations of the molecular gas and dust content in spiral galaxies within 25 Mpc. I review recent results on the molecular gas content and its relation to star formation, as well as on the gas to dust ratio and the dust heating in spiral galaxies. I also present new results on the effect of environment on the molecular gas content of spiral galaxies.