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Statistical design and the analysis of gene expression microarray data

Published online by Cambridge University Press:  08 June 2001

M. KATHLEEN KERR
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609 USA
GARY A. CHURCHILL
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609 USA
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Abstract

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Gene expression microarrays are an innovative technology with enormous promise to help geneticists explore and understand the genome. Although the potential of this technology has been clearly demonstrated, many important and interesting statistical questions persist. We relate certain features of microarrays to other kinds of experimental data and argue that classical statistical techniques are appropriate and useful. We advocate greater attention to experimental design issues and a more prominent role for the ideas of statistical inference in microarray studies.

Type
Review Article
Copyright
© 2001 Cambridge University Press